• br Acknowledgements br Funding This work was

  2021-11-19

  

  Acknowledgements Funding: This work was supported by the Instituto Nacional de Biomedicina do Semiárido (INCT-IBISAB-CNPq), Edital MCT/CNPq N° 014/2010 - Universal and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). Introduction Guanylin and uroguanylin are small, heat-

• Interestingly myorelaxation and the stimulation of

  2021-11-19

  

  Interestingly, myorelaxation and the stimulation of cGMP production are properties also reported for sGC stimulators, such as YC-1 and BAY 41–2272 (i.e., indazole compounds that were discovered in the 1990s) [35]. They relax aortic ring contractions induced by phenylephrine, and their effects are si

• GSTP is a class Glutathione

  2021-11-19

  

  GSTP1 is a π-class Glutathione S-transferase (GST-π) enzyme involved in tumor suppression by protecting pyrazine uses against genomic damage mediated by various oxidants. Although the loss of GSTP1 function by hypermethylation has been reported as a common epigenetic alteration in prostate carcinoge

• G protein coupled receptors GPCRs constitute a large

  2021-11-19

  

  G-protein coupled receptors (GPCRs) constitute a large family of 7 trans-membrane-spanning proteins that activate internal signal transduction cascades through binding to different ligands including neurotransmitters, peptides, and lipids [7]. This family of receptors has therapeutic potentials in t

• GPR shares a amino acid sequence identity in humans to

  2021-11-19

  

  GPR81 shares a 52% amino Vinblastine sulfate sequence identity in humans to GPR109A [1], [2], [3]. In addition, GPR81 is localized more specifically to the adipose tissue [3]. In 2008, lactate was discovered to be the endogenous ligand for GPR81 [9], [10]. Plasma lactate levels reach concentrations

• Because of its excellent GPR potency good

  2021-11-19

  

  Because of its excellent GPR119 potency, good hERG selectivity and favorable rat t, Fluorescein TSA Fluorescence System Kit was scaled-up and further profiled. The synthetic protocols described in , were both suitable for a multi-gram scale synthesis of compound . An off-target screen was perform

• Originally identified as a GPCR upregulated on Burkitt lymph

  2021-11-19

  

  Originally identified as a GPCR upregulated on Burkitt lymphoma cells upon Epstein-Barr virus infection (Birkenbach et al., 1993), Ebi2 was later found to play critical roles in immunity by regulating the migration of activated Aurora A Inhibitor I sale to extrafollicular sites for early plasmablas

• In the present study a significant increase

  2021-11-18

  

  In the present study, a significant increase in liver glut4 mRNA levels as well as an increase in liver glycogen content was observed in the dogfish in response to glucose-loading, although we did not observe any changes in liver glycogen content or glut mRNA levels following insulin administration

• For many plasma membrane receptors

  2021-11-18

  

  For many plasma membrane receptors including GPCRs, their density on the cell-surface is finely controlled by various transcriptional, post-transcriptional and post-translational mechanisms, and is often a determinant of overall receptor function in a cell. To date, the transcriptional regulation an

• In conclusion starting from the weakly potent

  2021-11-18

  

  In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic cyproheptadine hcl led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reported

• br Acknowledgments This research was supported in part

  2021-11-18

  

  Acknowledgments This research was supported in part by National Institutes of Health IDeA Program COBRE grant GM110732; a USDA National Institute of Food and Agriculture Hatch project; and the Montana State University Agricultural Experiment Station. Introduction Propofol (2,6-Diisopropylphen

• In the past two decades studies of the non B

  2021-11-18

  

  In the past two decades, studies of the non-B cell-derived Ig, including cancer cell-derived IgG, have been predominately facilitated by general anti-human Ig antibodies, which do not distinguish the non-B Ig from classical Ig derived from B cells. Due to this caveat, it remains obscure about whethe

• br FAAH mediation of fear and extinction In

  2021-11-18

  

  FAAH mediation of fear and extinction In addition to being a major target and modulator of stress, the BLA is a critical node within the neural circuitry subserving learned fear behaviors. The BLA is activated during the formation, expression, and extinction of conditioned fear memories, and dama

• Here we show in contrast to previous work that several

  2021-11-18

  

  Here we show, in contrast to previous work, that several phenotypes associated with Orb6 inactivation, including increased cell width, are independent of Gef1. We further find that Orb6 positively regulates exocytosis, also independently of Gef1. To identify novel targets of Orb6, we performed quant

• br To explore further the functional impact of the similarit

  2021-11-18

  

  To explore further the functional impact of the similarity of the UTY and KDM6A proteins, the FANTOM5 human dataset was analysed to determine whether or not the genes were expressed at the same time in the same tissues (which would suggest that they are controlled by the same regulators) or with o

16038 records 532/1070 page Previous Next First page 上5页 531532533534535 下5页 Last page