• Here we performed TEM and

  2021-11-29

  

  Here, we performed TEM and AFM imaging to study APE1–DNA interactions. The results showed that APE1 can dynamically polymerize on DNA in an apparently sequence-independent manner. We propose that this protein polymerization allows for scanning of the structural properties of DNA with short residence

• br Experimental procedures br Results br Discussion Although

  2021-11-29

  

  Experimental procedures Results Discussion Although the presence and localization of the GlyR subunits have been determined in the adult retina, the proportion of each GlyR subunit has not been assessed in the adult or in the developing retina. In the present study, we carried out the absol

• br Introduction Glucagon is a peptide hormone that

  2021-11-26

  

  Introduction Glucagon is a peptide hormone that acts to increase blood glucose levels. The secretion of glucagon from the alpha AZD2858 receptor of the islets of Langerhans in the pancreas is increased during fasting and prevents hypoglycemia. Glucagon increases glycogenolysis and gluconeogenesi

• PSB 0777 ammonium salt In contrast with the above

  2021-11-26

  

  In PSB 0777 ammonium salt with the above results, in our GC model system, FPR1-, but not FPR2-knockout, enhanced tumour formation. However, it should be noted that the prominent role of mFPR2 with respect to mFPR1 in the mouse colon might be due to the significantly higher expression of mFPR2 than

• In the phylum Cnidaria which separated from the

  2021-11-26

  

  In the phylum Cnidaria, which separated from the main line of Metazoa early during evolution, FGFR signaling is essential during development and morphogenesis. Two FGFRs and two FGFs antagonistically control formation of the apical organ in the anthozoan Nematostella and target the MAPK pathway (Ren

• Reports described a range of synthetic GPR

  2021-11-26

  

  Reports described a range of synthetic GPR40 agonists with desirable safety and efficacy profiles, compared with existing antidiabetic therapies such as insulin and sulfonylureas [[20], [21], [22], [23], [24], [25], [26], [27], [28]]. Among them, several small molecules were tested in the clinical t

• Through experimental models and clinical

  2021-11-26

  

  Through experimental models and clinical experiments, those four drugs above can shown efficacy-enhancing and toxicity-reducing effects after compatibility. Our preclinical studies showed that XFC has a definite effect on relieving joint symptoms in RA patients. XFC can improve joint pain, swelling,

• br Discussion The initial reduction and the

  2021-11-26

  

  Discussion The initial reduction and the subsequent increase in permeability proposes a regulatory process to control bleeding. However, following repeated injury, or during long-term presence of the inflammatory stimuli, these mechanisms may become defective and even detrimental. The expression

• The combination of HIV antigen and antibody testing with

  2021-11-26

  

  The combination of HIV antigen and antibody testing with the fourth generation immunoassays shortens the window Floxuridine for HIV by detecting HIV antigen, which appears in the blood before seroconversion [3,5,11,12]. Analysis of the seroconversion panels indicated the Elecsys® HIV Duo assay has

• br Patients and methods br

  2021-11-26

  

  Patients and methods Results Discussion The positivity of serum anti-HBc is the most commonly used marker to confirm the history of HBV infection. Quantification of serum anti-HBc has been explored as a marker of HBV-induced hepatitis and the adaptive immune response against HBV infection a

• br Introduction Excitatory pyramidal neurons are generated i

  2021-11-26

  

  Introduction Excitatory pyramidal neurons are generated in the cortical ventricular zone and migrate into the cortical plate alongside the radial glial processes (Chanas-Sacre et al., 2000, Hartfuss et al., 2001, Noctor et al., 2001, Rakic, 1972, Tan et al., 1998). Neuronal migration determines t

• Recent research reveals that human alkyladenine

  2021-11-25

  

  Recent research reveals that human alkyladenine DNA glycosylase (hAAG) is an important protein enzyme which can specifically recognize and excise a variety of alkylated purines and deoxyinosine from DNA [12]. hAAG plays pivotal roles in maintaining genomic integrity, and it is involved in Ketorolac

• br Methods and materials br Results and discussion br Conclu

  2021-11-25

  

  Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of Chlorpromazine HCl from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced by Aβ2

• During the tests in vitro SHP showed the beneficial effect

  2021-11-25

  

  During the tests in vitro, SHP289-04 showed the beneficial effect on both two important aspects. In human liver carcinoma cell line HepG2, it was found to improve glucose consumption significantly. Otherwise, in pancreas cell line NIT1, it could only promote insulin secretion significantly at high g

• FPR ligands comprise structurally very diverse classes of co

  2021-11-25

  

  FPR ligands comprise structurally very diverse Ginsenoside Rb1 of compounds, ranging from naturally occurring peptides/proteins or “danger signals” such as PAMPs and DAMPs (see 1.1), respectively, to endogenous lipids and even various synthetic non-peptides, such as benzimidazoles, pyrazolones, pyr

15712 records 506/1048 page Previous Next First page 上5页 506507508509510 下5页 Last page