• Excessive inflammation is an early systemic inflammatory res

  2018-11-05

  

  Excessive inflammation is an early systemic inflammatory response that can result in multiple organ failure and even death (Leclerc et al., 2011). miRNAs enriched in exosomes play a pivotal role in regulating inflammation (Wang et al., 2015). miR-155 and miR-146a are two critical regulators of infla

• Animal studies of myopia have shown that

  2018-11-05

  

  Animal studies of myopia have shown that atropine—a non-selective muscarinic gp120 receptor (mAChR) antagonist—effectively prevents the axial elongation, leading to myopia (Fan et al., 2007; Rada et al., 2000; Shih et al., 1999). Atropine inhibits myopia progression in the tree shrew, monkey, chick

• We have previously reported the CM chip that

  2018-11-05

  

  We have previously reported the CM chip that enables precise estimation of rare cell counts in blood including spiked-in cultured cancer dna ligase (Yatsushiro et al., 2010; Yamamura et al., 2012). Although the CM chip produced excellent results in a preclinical study, we considered that precise enu

• In conclusion the study by may open

  2018-11-05

  

  In conclusion, the study by may open an interesting perspective of predicting biomarker and provides option for a diagnostic approach from blood samples of HCC. These finding would potentially contribute to improvement in prediction and early detection of HCC development. Disclosure Bladder can

• Apart from oncology preclinical efficacy of PARP inhibitors

  2018-11-05

  

  Apart from oncology, preclinical efficacy of PARP-1 inhibitors in mitigating inflammation, circulatory shock, myocardial infarction, and stroke likely results from the inhibition of PARP-1-mediated transcription activation (Curtin & Szabo, 2013). It has been shown that transcriptional profiles are d

• Hypocretinergic activation during REM sleep

  2018-11-05

  

  Hypocretinergic activation during REM sleep is likely related to the activation that occur during certain patterns of somatomotor activity [50]. Although motor output is inhibited at the motoneuron level during REM sleep, supraspinal motor systems are very active during this state [60–62]. In fact,

• The above illustrations of the possibility

  2018-11-05

  

  The above illustrations of the possibility to trigger and monitor viscosity evolution of molecular reactions using a simple physical science method open up a wider array of biological or biomedical applications to directly monitor, for instance, the effect of a drug such as warfarin on blood viscosi

• br Experimental section br Results and discussion Building u

  2018-11-05

  

  Experimental section Results and discussion Building upon our previous work, we developed a water-stable sensor using rGO as the semiconducting channel material and Au NPs as the modular attachment points for immobilizing the probes [7]. This sensor enabled real-time sensing for in situ underw

• br Conflict of interest br Introduction Traditional

  2018-11-05

  

  Conflict of interest Introduction Traditional labels such as fluorophores, chromophores, or radioactive labels are widely used in microfluidic applications to visualize flow [1] or detect the presence or concentration of relevant species [2,3]. However, each of these labels has shortcomings in

• br Conclusion This paper numerically investigates propagatio

  2018-11-05

  

  Conclusion This paper numerically investigates propagation characteristics of proposed O-PCF, including confinement loss and sensitivity for a wide range of wavelength. The behavior of the proposed PCF for change of different parameters has been also investigated by using Water, Ethanol and Benzy

• A number of clinical proteomics studies have

  2018-11-03

  

  A number of clinical proteomics studies have generated a long list of candidate urine protein biomarkers of various diseases (Beretov et al., 2015; Goodison et al., 2009; Rodriguez-Suarez et al., 2014; Shao, 2015); however, no biomarkers derived from ‘discovery’ studies were successfully translated

• In the present study we identified

  2018-11-03

  

  In the present study, we identified novel NFAT5 suppressors for use in RA therapies. We screened >40,000 small molecules which suppress NO induction and then validated anti-NFAT5 activity of the candidate molecules using an NFAT5-specific reporter. As a result, we discovered the novel NFAT5 inhibito

• Forskolin Compared to fMRI BOLD signals which map neural act

  2018-11-03

  

  Compared to fMRI BOLD signals, which map neural activity by imaging haemodynamic responses, DC-EEG offers a more direct measure of spontaneous VLF oscillations (VLFOs), albeit with relatively limited spatial resolution. While the functional significance of VLFOs and its relation to BOLD signals cont

• Along with increases in fronto parietal

  2018-11-03

  

  Along with increases in fronto-parietal activation, task-related decreases are frequently seen in a set of regions including the vACC and posterior cingulate clinical trial (PCC) commonly known as the default network (Greicius and Menon, 2004; Greicius et al., 2003; Raichle and MacLeod, 2001; Shulm

• We argue here that memory

  2018-11-03

  

  We argue here that memory is far from unitary. Improvements in the precision of lesion studies (e.g., Heuer and Bachevalier, 2011; Pascalis et al., 2009) and imaging in human adults (e.g., Bakker et al., 2008; Ranganath, 2010; Staresina et al., 2011) demonstrate that MTL supports diverse forms of me

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