Kearns et al demonstrated that dCas transcriptional

2018-10-20

Kearns et al. (2014) demonstrated that dCas9 transcriptional activators and repressors can be used to control human pluripotent stem cell differentiation by targeting endogenous SOX17 and OCT4. We have expanded the target gene list to additional key factors in the endodermal and pancreatic different

Introduction The correct functioning of the

2018-10-20

Introduction The correct functioning of the epigenome ensures fidelity in the establishment of gene-expression programs that are compatible with specific cell identities. The need for tightly controlled epigenetic landscapes is of critical importance for stem cells, which are able to both self-rene

br Introduction Bone marrow derived mesenchymal stromal cell

2018-10-20

Introduction Bone marrow-derived mesenchymal stromal cell (BM-MSC)-derived osteoblasts and chondrocytes are responsible for bone and cartilage modeling/remodeling, respectively (Harada and Rodan, 2003; Wu et al., 2009). Osteoblasts are defined by lineage-specific transcription factors RUNX2 and O

Introduction The pluripotency promoting role of the reprogra

2018-10-20

Introduction The pluripotency-promoting role of the reprogramming factors OCT4, SOX2, KLF4, and MYC (OSKM) is widely appreciated. However, these reprogramming factors also promote expression of non-pluripotency genes. For example, OCT4 (Pou5f1) directly promotes expression of genes important for mo

Hello world!

2018-07-29