• The importance of the microenvironment for cancer developmen

  2019-04-16

  

  The importance of the microenvironment for cancer development and progression is now widely recognised, but it is worth reminding ourselves that this is a relatively young area of research. Anyone searching PubMed today using the terms “” will find over 22,000 scientific publications, with around 30

• br Case An year old man with no

  2019-04-16

  

  Case 1 An 81-year-old man with no history of kinesin inhibitor disease was admitted to our hospital for the treatment of recurrent episodes of syncope after drinking. He experienced the first episode at age 75. On admission, his blood pressure (BP) was 144/81mmHg and the heart rate (HR) was 56be

• Causative genes for ARVC and their respective characteristic

  2019-04-16

  

  Causative genes for ARVC and their respective characteristics are summarized in Table 1. Desmosome genes for ARVC Other causative genes for ARVC Although more than half of ARVC patients carry mutations in desmosome genes, other genes have also been reported as causative genes for ARVC (Table

• Second although it is an important and biologically plausibl

  2019-04-16

  

  Second, although it is an important and biologically plausible refinement, risk-factor adjustment based on lack of access to improved water in rural areas and urban slums could be open to criticism, as the authors acknowledge. The imperfect relation between access to improved water and consumption o

• A critical link exists between awareness of risk the

  2019-04-15

  

  A critical link exists between awareness of risk, the presence of disease, and steps taken by the patient and clinician to change the natural history of disease. Chronic illnesses such as diabetes mellitus, dyslipidaemia, anaemia and a multitude of endocrinological and rheumatological diseases are r

• The WHO guidance promotes pre exposure prophylaxis for

  2019-04-15

  

  The 2016 WHO guidance promotes pre-exposure prophylaxis for all populations with an incidence of HIV above three per 100 person-years. This guidance is, some ways, an indictment on the promotion of condoms in HIV prevention. However, WHO does not retract its message regarding the use of condoms. The

• Although these studies demonstrated the efficacy of

  2019-04-15

  

  Although these studies demonstrated the efficacy of pacemaker treatment for preventing or reducing VVS, all 3 trials were retrospective and uncontrolled [10]. Therefore, RCTs of cardiac pacing in VVS were proposed in the late 1990s. The era of RCTs: is pacemaker efficacy due to a placebo effect?

• DALYs as a tool for measuring

  2019-04-15

  

  DALYs, as a tool for measuring the burden of breast cancer, is useful for public health and for burden of disease analyses. DALYs can add useful available information for monitoring services and conducting health-related economic analyses for cost-effective planning in the country. As noted earlier,

• The pathophysiology underlying ONJ is unclear Decreased bone

  2019-04-15

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• Expansion of access to HIV treatment

  2019-04-15

  

  Expansion of access to HIV treatment is a global priority. In July, 2013, UNAIDS, in collaboration with WHO, the Global Fund to fight AIDS, Tuberculosis and Malaria, and the US President\'s Emergency Plan for AIDS Relief (PEPFAR) jointly issued which advocates for a worldwide treatment target of 15

• br Introduction Worldwide trauma is currently

  2019-04-15

  

  Introduction Worldwide, trauma is currently the sixth leading cause of death, accounting for 10% of mortalities. The urogenital system has consistently been shown to be involved in 10% of patients presenting after trauma and is a significant factor in trauma-induced morbidity and mortality. Renal

• br Conclusiones br LA REVISTA DE FILOSOF A Para la

  2019-04-11

  

  Conclusiones LA REVISTA DE FILOSOFÍA Para la época en que se publicaba la Revista de Filosofía, Cultura, Ciencias y Educación, José Ingenieros lideraba una agrupación nucleada en torno GSK503 intereses intelectuales y afinidades personales que recuperaba, aunque con mucha más moderación, forma

• Igualmente podr a ampliarse su cr tica a la

  2019-04-11

  

  Igualmente, podría ampliarse su crítica Ozanimod la modernidad occidental, entendida como proyecto civilizatorio orientado por la totalización de la racionalidad instrumental y el mito del progreso. La modernidad occidental no es sólo expresión de una racionalidad fetichizada. En tanto capitalismo g

• Hypocretinergic activation during REM sleep

  2018-11-15

  

  Hypocretinergic activation during REM sleep is likely related to the activation that occur during certain patterns of somatomotor activity [50]. Although motor output is inhibited at the motoneuron level during REM sleep, supraspinal motor systems are very active during this state [60–62]. In fact,

• Modafinil is a non amphetamine stimulant that

  2018-11-15

  

  Modafinil is a non-amphetamine stimulant that promotes the vigil state, whose mechanism of action is still not fully understood. However, it has been demonstrated that modafinil acts via the blockage of dopamine transporter (DAT) and also the noradrenalin transporter (NET). Besides having these adre

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