• br Material and methods br Results br Discussion

  2019-04-19

  

  Material and methods Results Discussion The present study provides clinical, molecular, and in vitro electro-physiological evidence that a rare SNP (KCNE1-D85N) can act as a genetic modifier in LQTS. In general, SNPs are thought to be non-pathological, but some have been reported to modify

• br Mechanisms of ventricular fibrillation electrical storm i

  2019-04-19

  

  Mechanisms of ventricular fibrillation/electrical storm in the Brugada syndrome patients One of the most consistent features of BrS is that premature ventricular contraction (PVC), which triggers VF, is almost always short-coupling [3,4]. An interesting phenomenon is that many of the VF episodes

• br Commentary The concept of entrainment

  2019-04-19

  

  Commentary The concept of entrainment mapping for ablation of VT is that targeting the site will interrupt the reentrant VT circuit. This site must be located, not only within the circuit, but also in a protected and relatively narrow isthmus. During entrainment mapping, the QRS morphology, S-QR

• Sultan et al retrospectively searched the surveillance

  2019-04-19

  

  Sultan et al retrospectively searched the surveillance, epidemiology, and end results (SEER) database for patients who were diagnosed with NPC from 1988 to 2006. They compared the clinical features and outcomes of 129 children and adolescents ( Epstein-Barr virus (EBV) infection, a higher rate of un

• The Cochrane review on exercise after

  2019-04-19

  

  The Cochrane review on exercise after lung resection identified three randomized trials involving 178 participants. The meta-analysis found that exercise capacity was statistically greater in the exercise training group compared to the control group following lung resection for NSCLC. No between-gro

• The diagnosis of vasovagal syncope is usually

  2019-04-19

  

  The diagnosis of vasovagal syncope is usually based on a combination of careful history taking, clinical examination, and a surface electrocardiogram to exclude cardiac and non-cardiac causes of syncope [3,4]. When the etiology of syncope is uncertain, head-up tilt-table testing (HUTT) is commonly u

• ras pathway The most compelling apparent evidence in

  2019-04-19

  

  The most compelling apparent evidence in support of the depolarization hypothesis derives from the seminal studies of Nademanee et al. [129]. showing that radiofrequency ablation (RFA) of epicardial sites displaying late potentials and fractionated bipolar electrograms in the RVOT of patients with B

• Interestingly it was reported that both salicylate

  2019-04-18

  

  Interestingly, it was reported that both salicylate and APAP activate p38 MAPK [13,14]. Furthermore, it is known that p38 MAPK is responsible for the phosphorylation of S538 in gp78. Phosphorylation of gp78 by p38 MAPK inhibited the degradation of mitofusin 1 (MFN1), a mitochondrial protein that be

• Introduction Implantable cardioverter defibrillators ICD car

  2019-04-18

  

  Introduction Implantable cardioverter-defibrillators (ICD), cardiac resynchronization therapy defibrillators (CRT-D), and cardiac resynchronization therapy (CRT-P) are useful tools for improving the prognosis and/or sudden cardiac death event rate in patients with heart failure and/or fatal ventric

• br Discussion Digoxin has multiple effects on

  2019-04-18

  

  Discussion Digoxin has multiple effects on the myocardium and has multiple cardiac-related uses. In the treatment of atrial fibrillation, digoxin increases vagal tone to prolong the refractory PLX-4720 at the AV node, decreasing ventricular response to higher atrial rates [3]. Toxic doses of digo

• br Introduction Magnetic resonance imaging MRI has great uti

  2019-04-18

  

  Introduction Magnetic resonance imaging (MRI) has great utility in evaluating musculoskeletal tumors. However, some lesions have an appearance on MRI that make it challenging to differentiate benign from malignant lesions. Even intravenous (IV) Erastin sometimes does not allow differentiation of

• The presence of an inflammatory infiltrate is associated wit

  2019-04-18

  

  The presence of an inflammatory infiltrate is associated with poor prognosis in a number of malignancies, including those with a predilection for metastasis to bone. CAFs are capable of promoting, and maintaining an inflammatory environment by recruiting immune cells; in particular monocyte/macropha

• br Discussion This study shows that

  2019-04-18

  

  Discussion This study shows that the risk of all-cause mortality in patients with atrial fibrillation is directly associated with RDW in a dose-response manner. This association was independent of known risk factors of mortality. Notably, RDW is associated with all-cause mortality regardless of a

• br Although safe effective evidence based interventions that

  2019-04-18

  

  Although safe, effective, evidence-based interventions that na inhibitor are simple enough to be provided at primary-care level exist, provision of safe abortion remains restricted to physicians and often only to gynaecologists in many parts of the world. WHO\'s new guideline highlights that mov

• br Results There were cases where

  2019-04-17

  

  Results There were 232 cases where cryotherapy was used in 214 patients between 1994 and 2015. There were 96 male and 118 female. The age of patients ranged from 4 to 95. All patients had undergone imaging studies for evaluation. A majority of cases consisted of active or aggressive benign tumors

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