• Naumann et al reported that the absolute

  2018-10-24

  

  Naumann et al. (2010) reported that the absolute number of BrdU+ cells at 4 weeks after the last BrdU injection was similar between hAPP-I5 and control mice, which is inconsistent with our results. One possibility for this discrepancy might be the age of mice used in the studies. Six-week-old mice w

• As a marker of cochlear supporting

  2018-10-24

  

  As a marker of cochlear supporting cells, we assessed P27Kip1 localization in iCx26GJCs. P27Kip1 is a cyclin-dependent kinase inhibitor that is thought to play a role in maintaining the postmitotic state of cochlear supporting daidzin such as the Deiters\' cells and outer- and inner-sulcus cells. Th

• carnosic acid Given these findings StemCells Inc sponsored a

  2018-10-24

  

  Given these findings, StemCells, Inc. sponsored a third-party review by a CRO. In this report, the CRO veterinary pathologist concluded that “there is no morphologic evidence of neoplastic transformation in the cell population.” The veterinary pathologist also stated that “the cellular morphology is

• Human liver chimeric mice carrying human pHH can

  2018-10-24

  

  Human liver chimeric mice carrying human pHH can facilitate in vivo study of viral hepatitis infections (Bissig et al., 2010; Carpentier et al., 2014) and liver genetic diseases (Bissig-Choisat et al., 2015; Yusa et al., 2011), and the testing of small molecular drug candidates and biological compon

• The tissue specific homing and activities of MSCs

  2018-10-24

  

  The tissue-specific homing and activities of MSCs that have been cultured in vitro prior to transfusion are likely based on an underlying transcriptional code caused by epigenetic memory allowing them to home back to the tissue from which they originally were derived (Frobel et al., 2014). We have p

• br Results br Discussion Comparative analyses

  2018-10-24

  

  Results Discussion Comparative analyses of non-neoplastic and neoplastic human neural populations, isolated ex vivo from fresh pathology samples, are technically challenging but can yield important insight into both normal biology and gliomagenesis. Here we provide a useful ligand-based method

• melanocortin receptor Here using hNPCs derived from RTT pati

  2018-10-24

  

  Here, using hNPCs derived from RTT patient iPSCs as an example, we have shown that our method of hypoxia-mediated rapid astrocytic differentiation of hNPCs can be applied to functional analysis of patient-derived astrocytes. We revealed that MECP2 MT astrocytes diminish the soma size, neurite outgro

• The nanofilm refractive index n and the thickness d

  2018-10-24

  

  The nanofilm refractive index n and the thickness d (in nm) were measured with the use of a spectral ellipsometer HORIBA Jobin Yvon. Integral light transmission T (in %) of nanocomposite samples in the visible spectral range of 400–800 nm was recorded with a microspectrometer FSD-8 and processed wit

• Age adjusted odds ratios AOR of morbid obesity

  2018-10-24

  

  Age-adjusted odds ratios (AOR) of morbid obesity by income and by education are presented in Tables 2 and 3. These estimates confirm a graded association of morbid obesity with income and education category in both English men and women. In the lowest category of income, compared with the highest, t

• Several ongoing clinical trials are evaluating the feasibili

  2018-10-23

  

  Several ongoing clinical trials are evaluating the feasibility of combining chemotherapeutic nanomedicines with radiotherapy or small molecule drugs (such as gemcitabine). Pegylated liposomal doxorubicin has shown improved therapeutic efficacy when combined with radiotherapy in several animal studie

• Children with CRS may be

  2018-10-23

  

  Children with CRS may be infectious for the entire first year of life, rarely even longer (Cooper and Krugman, 1967; Rawls et al., 1967), and can transmit the virus causing infection in non-immune individuals (Hardy et al., 1965; Greaves et al., 1982; Schiff and Dine, 1965). The infant mortality rat

• N6022 br Conflicts of Interest br Author Contributions br Ac

  2018-10-23

  

  Conflicts of Interest Author Contributions Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science (JSPS) and the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) (Grant num

• The US Department of Agriculture USDA

  2018-10-23

  

  The US Department of Agriculture (USDA) and US Department of Health and Human Services recommend 2 cups (3–4 servings (U.S. Department of Health and Human Services and U.S. Department of Agriculture, 2000)) of trifluoperazine per day for active women. One cup of fruit (U.S. Department of Health and

• As a potential therapeutic target

  2018-10-23

  

  As a potential therapeutic target, the pleiotropic actions of prolactin engender both excitement and frustration. Excitement, because clear beneficial actions shown in the lab seem to have huge potential for developing new treatments. Frustration, because with so many other tissues possibly influenc

• Histidine rich glycoprotein HRG is a kDa plasma glycoprotein

  2018-10-23

  

  Histidine-rich glycoprotein (HRG) is a 75kDa plasma glycoprotein produced in and secreted from the liver (Koide et al., 1986). The plasma levels of HRG in healthy human were reported to be constant around 1μM (Poon et al., 2011). HRG\'s primary amino d-xylose sequence has an extraordinary number of

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