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          br Conflict of interest br2019-06-19  Conflict of interest Introduction Garrigue et al. reported that atrial overdrive pacing reduces the number of sleep Aurora Kinase Inhibitor III episodes in pacemaker patients without heart failure [1]. However, this finding has not been replicated in subsequent investigations [2–5], although 
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          br Diagnostic criteria Brugada syndrome is definitively diag2019-06-19  Diagnostic criteria Brugada syndrome is definitively diagnosed when a type-1 ST-segment elevation is observed in at least 1 right precordial lead (V1 and V2) [23], placed in a standard or a superior position (up to the second intercostal space) (Fig. 1C) [24,25], in the presence or absence of a s 
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          Regarding the expression of NKp NCR2019-06-18  Regarding the expression of NKp46/NCR1 (Fig. 1A and B), both increased and decreased expression are observed depending on patients. Interestingly, the expression of the inducible molecule NKp44/NCR2 is clearly induced in 3 patients (PT1, PT2 and PT5) both regarding the percentage and the MFI. In con 
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          In the past two decades several studies2019-06-18  In the past two decades, several studies have consistently found that up to one-sixth of cancers worldwide are attributable to infectious pathogens. Cancers caused by infectious agents present unique opportunities for prevention and treatment; therefore, a detailed understanding of how infections co 
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          Chronic hepatitis B virus HBV infection is prevalent in2019-06-18  Chronic BAY 41-8543 virus (HBV) infection is prevalent in many Asian countries, notwithstanding three decades of universal hepatitis B vaccination programs. The invention of nucleos(t)ide analogs (NUCs) was a breakthrough in the treatment of chronic hepatitis B (CHB). However, HBV continues to be a 
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          purchase FAK Inhibitor 14 br Risk of bleeding complications2019-06-18  Risk of bleeding complications with dual antiplatelet agents Dual antiplatelet therapy (DAPT) with combined aspirin and clopidogrel has become a standard treatment after percutaneous coronary intervention (PCI). Recent studies have examined the impact of such therapy on the incidence of bleeding 
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          Elderly patients especially those in excess of years2019-06-18  Elderly patients, especially those in excess of 70 years of age, are often quite fragile; such fragility may be secondary to aging or comorbidity. In this “susceptible” patient population, the negative influence of ET-adverse events on patient adherence to a medication regimen can be elevated. This 
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          br Primary biliary cholangitis Primary biliary cholangitis P2019-06-18  Primary biliary cholangitis Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is another rare but devastating immune-mediated cholangiopathy. Similar to PSC, PBC is characterized by portal inflammation leading to fibrosis and eventually cirrhosis. Distinct from PSC 
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          As Canadians queue to vote in2019-06-18  As Canadians queue to vote in the federal election next week, some will be uncomfortable knowing that the new Fair Elections Act that requires an official photo identification will overwhelmingly discriminate against those who are least likely to produce it—the very groups cited by UNCOHR. Many Cana 
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          br IntroduccI n Entre los2019-06-18  IntroduccIón Entre los años 1990 y 2013 se han aplicado en Chile once tipos de evaluaciones estandarizadas: las nacionales sImce, paa, psu e internacionales perce, tImss, cIved, pIsa y pIsa +, serce, Iccs, terce. Los resultados han sido, indefectiblemente, los mismos: siempre les va mal Almorexan 
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          To date no biomarker analyses2019-06-17  To date, no biomarker analyses of response to VEGFR targeting agents in breast cancer patients with bone predominant metastatic disease has occurred. Although the bone turnover markers serum c-telopeptide (sCTx), and urinary N-telopeptide (uNTx) were measured at baseline, and uNTX measured every 8 w 
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          br Treatment and follow up recommendations for patients rece2019-06-17  Treatment and follow-up recommendations for patients receiving aromatase inhibitors Conclusions and future directions It is evident that, in addition to BMD, clinical risk factors can greatly influence fracture risk. In addition to morbidity and mortality, fractures are associated with high he 
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          br Methods br Results br Discussion The results2019-06-17  Methods Results Discussion The results of this study demonstrate that (1) low-dose landiolol (0.5μgkg−1min−1) prevent heart rate elevation after AF ablation; (2) prophylactic administration of low-dose landiolol successfully prevented immediate AF recurrence within 3d after AF ablation with 
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          br Conclusions br Conflict of interest br Introduction Arrhy2019-06-17  Conclusions Conflict of interest Introduction Arrhythmogenic right ventricular cardiomyopathy (ARVC), previously called arrhythmogenic right ventricular dysplasia (ARVD), is an inherited disease characterized by right ventricular degeneration and ventricular arrhythmias. ARVC is one of the 
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          Es un hecho innegable que2019-06-17  Es un hecho innegable que la descripción que Servando Teresa de Mier plasma en sus Memorias (escritas en las cárceles inquisitoriales de Nueva España entre 1818 y 1820) sobre su estadía forzada en Europa por más de veinte años presenta exageraciones sobre el castigo que la Inquisición española le im 
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