• Replicative senescence is another condition that can be

  2018-11-12

  

  Replicative senescence is another condition that can be preceded and propagated by a very similar cascade of proinflammatory signals, which is called a senescence-associated proinflammatory phenotype (SASP) (Velarde et al., 2013). Since this SASP can “infect” neighboring glycine receptors a conditio

• Progression of maladaptive LV remodeling

  2018-11-12

  

  Progression of maladaptive LV remodeling, increased wall stress and transition to heart failure are associated with an enhanced cardiac production of natriuretic peptides (Hohl et al. 2013; van Veldhuisen et al. 2013). TAC led to a marked five- to twenty-fold increase of myocardial BNP and ANP expre

• Herein we describe increased VEGFA and SEMA A expression in

  2018-11-09

  

  Herein, we describe increased VEGFA and SEMA3A expression in bone marrow angiotensin receptor blockers from de novo AML patients and the possible dominant effect of SEMA3A, suggesting that SEMA3A could control the effects caused by VEGFA. However, some questions remain: Why is SEMA3A expression inc

• br Results br Discussion Here we report on different mutant

  2018-11-09

  

  Results Discussion Here we report on 14 different mutant hESC lines, termed DM1 hESCs, that were derived from DM1-affected preimplantation embryos. Previous studies employed DM1 hESCs to explore the causal role of CTG expansion on neurite formation and neuromuscular connections and for charact

• br Results br Discussion Following transplantation into immu

  2018-11-09

  

  Results Discussion Following transplantation into immunodeficient mice, immature hESC-derived pancreatic progenitor phospholipase a2 inhibitor develop over a lengthy maturation period into glucose-responsive, insulin secreting cells (Rezania et al., 2012; Bruin et al., 2013), although this pro

• In comparison with CSCs from tumors derived from

  2018-11-09

  

  In comparison with CSCs from tumors derived from other tissues, the nature of MM CSCs with respect to niche, interactions with the microenvironment, and most importantly the immune system and other properties in vivo are as yet under exploited. We estimate that the EGFP-based approach will allow als

• Our current study also enabled the assessment of

  2018-11-09

  

  Our current study also enabled the assessment of clonal contribution to in vivo multilineage hematopoiesis from single dna staining at the earliest stages of HSC precursor formation, which has allowed us to identify the earliest common precursor of B-1a and B-2 cell potential in a clonal precursor t

• br Deposition of MgSe thin films MgSe thin solid films

  2018-11-09

  

  Deposition of MgSe thin films MgSe thin solid films were prepared using the versatile spray pyrolysis technique, which is simple and economic as compared to the MBE and MOCVD methods. The properties of the film can be controlled by adjusting the preparative parameters such as substrate temperatur

• Hone et al Hone Jarden Schofield Duncan contend

  2018-11-09

  

  Hone et al. (Hone, Jarden, Schofield, & Duncan, 2014) contend that policy-makers are increasingly interested in assessments of health that include measures of positive mental health and well-being, with an emphasis on strengths-based approaches as opposed to an illness-focus. Positive mental health

• br Materials and methods br Results and discussion br Conclu

  2018-11-09

  

  Materials and methods Results and discussion Conclusion An RSM based on CCRD and a multi-layer neural network (4-5-1 ANN architecture) models were developed in order to justify the aim of the current research. The input variables were temperature, time, volume of solvent, and particle size,

• While MRI studies may offer anatomical insight about connect

  2018-11-09

  

  While MRI studies may offer anatomical insight about connectivity in autism, they lack temporal resolution. EEG and magnetoencephalography (MEG) studies provide a means of evaluating this parameter of functional connectivity. These coherence studies generally analyze the phase shift and amplitude ra

• This study is important because our ability to identify

  2018-11-09

  

  This study is important because our ability to identify enough SNPs for a risk profile for clinical implementation is dependent on combining multiple heterogeneous cohorts. The aim was to show that multi-center radiotherapy cohorts could be harmonized and analyzed to identify risk SNPs by increasing

• Profiling of multiple gene expression by

  2018-11-09

  

  Profiling of multiple gene sphingosine by qRT-PCR or microarray, such as 21-gene testing and 70-gene MammaPrint signature, has been used in clinical practice to provide prognostic information and help in clinical decision for breast cancer patients. These assays have been approved to be used in clin

• The extracellular matrix ECM is important for

  2018-11-09

  

  The extracellular matrix (ECM) is important for the integrity of the aortic wall and mutations in ECM genes such as Fibulin-4 and Fibrillin-1 hence lead to aneurysm formation. Genetic studies in Fibulin-4 and Fibrillin-1 mutant mice implicated dysregulation of the TGF-β pathway as an important hallm

• In this issue of Matsumoto et al report the second

  2018-11-09

  

  In this issue of , Matsumoto et al. report the second clinical trial of nationally-regulated encapsulated porcine islet xenotransplantation, conducted in Argentina (). From their previous experience, the authors speculated that a large islet mass was susceptible to injury from oxygen and/or nutrient

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